Projects
» Dysphagia
Dysphagia is a frequent symptom after stroke and if not diagnosed and treated, this might result in pneumonia. In this study we want to differentiate the cerebral representation of the oral and pharyngeal phase of swallowing in healthy volunteers. In a next step we are interested in the changes of control of swallowing movements after increasing effort. In another study we will investigate age related changes of swallowing representation. This will enable us to compare reorganized swallowing representation of recovered patients and detect beneficial recruitment of swallow movements.
Above: Illustration of a brainstem lesion with resulting dysphagia and diffusion tractography of the continuous pathway systems (percent disconnected fibre map).
Publications:
Domin M., Mihai G.P., Platz T., Lotze M. (2022) Swallowing function in the chronic stage following stroke is associated with white matter integrity of the callosal tract between the interhemispheric S1 swallowing representation areas. Neuroimage Clinical, 35 (2022) 103093
Mihai, P.G., Otto, M., Domin, M., Platz, T., Hamdy, S., Lotze, M. (2016) Brain imaging correlates of recovered swallowing after dysphagic stroke: an fMRI and DWI study. Neuroimage Clinical, 2:1013-1021.
Windel AS*, Mihai PG*, Lotze M. (2015) Neuroimaging of swallowing in the elderly, Behavioral Brain Research, 286:308-17.
Mihai P.G., Otto M., Platz T., Eickhoff S.B., Lotze M. (2014) Sequential evolution of cortical activity and effective connectivity of swallowing using fMRI. Human Brain Mapping,35(12): 5962-73.
Mihai PG, von Bohlen und Halbach O, Lotze M (2013) Differentiation of cerebral representation of occlusion and swallowing with fMRI. Am J Physiol. 304(10):G847-54.
Lotze M., Seggewies G., Erb M., Grodd W., Birbaumer N. (2000) The representation of articulation in the primary sensorimotor cortex. NeuroReport 11: 2985-2989.
This study has been supported by a grand from the German Research Foundation (LO 795/12-1 and 12-2).
